A Standardized Workflow for Hyperpolarized ¹²⁹Xe MRI to Study Pulmonary Function

November 21, 2023

Acquiring Hyperpolarized ¹²⁹Xe Magnetic Resonance Images of Lung Ventilation

01:55 min

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Pre-Scan Preparation and Coaching of Subject for ¹²⁹Xe MRI of Lung Ventilation

01:53 min

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Preparation of MRI Scanner Room and Subject Positioning for ¹²⁹Xe MRI of Lung Ventilation

02:35 min

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Performing ¹²⁹Xe MRI Scan of Lung Ventilation to Assess Pulmonary Function

02:57 min

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William J. Garrison, John P. Mugler III², Jaime F. Mata, Roselove N. Nunoo-Asare, Y. Michael Shim, G. Wilson Miller^2,4

¹Department of Biomedical Engineering,University of Virginia, ²Department of Radiology and Medical Imaging,University of Virginia, ³Department of Medicine,University of Virginia, ⁴Department of Physics,University of Virginia

Summary

Hyperpolarized ¹²⁹Xe magnetic resonance imaging (MRI) is a method for studying regionally resolved aspects of pulmonary function. This work presents an end-to-end standardized workflow for hyperpolarized ¹²⁹Xe MRI of lung ventilation, with specific attention to pulse sequence design, ¹²⁹Xe dose preparation, scan workflow, and best practices for subject safety monitoring.

A Standardized Workflow for Hyperpolarized 129Xe MRI to Study Pulmonary Function

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation

Pre-Scan Preparation and Coaching of Subject for 129Xe MRI of Lung Ventilation

Preparation of MRI Scanner Room and Subject Positioning for 129Xe MRI of Lung Ventilation

Performing 129Xe MRI Scan of Lung Ventilation to Assess Pulmonary Function