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Mouse Extended Hepatectomy Model for Liver Regeneration Studies

May 24th, 2024
1, 1, 1, 1, 1, 1,2
1Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, 2The Transplant Institute and the Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School

Summary
Automatic Translation

Musemodellen med partiell 2/3 (66 %) hepatektomi er godt beskrevet i litteraturen, men mer utvidede hepatektomier som etterligner små-for-størrelse-syndrom etter levertransplantasjon har sjelden blitt brukt. Vi beskriver en utvidet 78 % hepatektomiprosedyre i en musemodell som resulterer i omtrent 50 % postoperativ dødelighet hos friske mus.

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