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定向脑深部结构与配送药品，病毒载体，或细胞移植Microinjections

JoVE Journal
Neurociência

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JoVE Journal Neurociência

Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants

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定向脑深部结构与配送药品，病毒载体，或细胞移植Microinjections

DOI:

•

07:00 min

•

December 01, 2010

•

Oscar Gonzalez-Perez, Hugo Guerrero-Cazares, Alfredo Quiñones-Hinojosa

¹ Neuroscience Lab/ Fac. Psicologia,University of Colima, ²Department of Neurosurgery,Johns Hopkins University

Capítulos

00:05Título
00:55Introduction
01:18Constructing Glass Needles
02:36Using the Needles for Microinjections into the Rodent Brain
06:06Representative Microinjection Results
06:36Conclusion

Summary

Tadução automática

在这篇文章中，我们将展示一种方法，使与50微米的管腔玻璃毛细管针。这种技术大大降低大脑的损害，最大限度地减少药物的被动扩散，并允许一个精确的定位到啮齿类动物的大脑。

Tags

Deep Brain Structures Microinjections Drug Delivery Viral Vectors Cell Transplants Brain Parenchyma Injecting Needle Brain Lesion Mouse Brain Glass Capillary Needles Brain Damage Precise Targeting Rodent Brain Small Volumes Bleeding Risks Passive Diffusion Injection Techniques Collateral Damage

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