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1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine,University of California at Los Angeles, 2Crump Institute for Molecular Imaging, David Geffen School of Medicine,University of California at Los Angeles, 3California NanoSystems Institute,University of California at Los Angeles, 4Nuclear Medicine, PET Center, Shanghai Medical Collegea,Fudan University, 5Electronics and Information Engineering, College of Electronics and Information Engineering,Wuhan Textile University
Capítulos
- 00:05Título
- 01:51Preparation for [18F]SFB Synthesis
- 03:03[18F]SFB Synthesis
- 04:44Preparation of Solid Phase Extraction (SPE)-purified [18F]SFB
- 07:24Representative Results for the Microwave-assisted One-pot Synthesis of [18F]SFB
- 08:10Conclusion
Une facile, un pot de synthèse du N-succinimidyl-4-[<sup> 18</sup> F] fluorobenzoate ([<sup> 18</sup> F] SFB) a été développé basé sur une non-aqueuse, un processus en trois étapes radiochimique. Utilisant un chauffage à micro-ondes, toute la procédure peut être complété en moins de 30 min ou 60 min avec une purification supplémentaire par HPLC préparative. La décroissance des rendements corrigés radiochimique (RCYs) étaient 35-5% (n> 30).
Tags
Microwave-assistedOne-pot SynthesisN-succinimidyl-4-[18F]fluorobenzoate[18F]SFBBiomoleculesPeptidesProteinsAntibodiesEngineered FragmentsTherapeuticsMolecular Imaging AgentsPositron-emitting RadioisotopesCu-64Ga-68F-18Targeted ImagingPhysiological ProcessesPathological ProcessesSynthesisExploration18F-labeled BiomoleculesDirect 18F-labelingOrganic SolventExtreme PHHigh TemperatureRadiolabeled Prosthetic GroupsMethod Of ChoiceBolton-Hunter Type ReagentPrimary Amino GroupsIn Vivo StabilityRadiolabeling YieldPET Tracers
