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1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine,University of California at Los Angeles, 2Crump Institute for Molecular Imaging, David Geffen School of Medicine,University of California at Los Angeles, 3California NanoSystems Institute,University of California at Los Angeles, 4Nuclear Medicine, PET Center, Shanghai Medical Collegea,Fudan University, 5Electronics and Information Engineering, College of Electronics and Information Engineering,Wuhan Textile University
Capítulos
- 00:05Título
- 01:51Preparation for [18F]SFB Synthesis
- 03:03[18F]SFB Synthesis
- 04:44Preparation of Solid Phase Extraction (SPE)-purified [18F]SFB
- 07:24Representative Results for the Microwave-assisted One-pot Synthesis of [18F]SFB
- 08:10Conclusion
Bir uyduruk bir pot sentez N succinimidyl-4-[<sup> 18</sup> F] fluorobenzoate ([<sup> 18</sup> F] SFB) susuz, üç adım radyokimyasal süreci dayalı geliştirilmiştir. Mikrodalga ısıtma kullanarak, tüm işlemleri en az 30 dakika veya daha fazla arıtma preparatif HPLC ile 60 dakika içinde tamamlanabilir. Çürüme düzeltilmiş radyokimyasal verimleri (RCYs) 35-5 (% n> 30).
Tags
Microwave-assistedOne-pot SynthesisN-succinimidyl-4-[18F]fluorobenzoate[18F]SFBBiomoleculesPeptidesProteinsAntibodiesEngineered FragmentsTherapeuticsMolecular Imaging AgentsPositron-emitting RadioisotopesCu-64Ga-68F-18Targeted ImagingPhysiological ProcessesPathological ProcessesSynthesisExploration18F-labeled BiomoleculesDirect 18F-labelingOrganic SolventExtreme PHHigh TemperatureRadiolabeled Prosthetic GroupsMethod Of ChoiceBolton-Hunter Type ReagentPrimary Amino GroupsIn Vivo StabilityRadiolabeling YieldPET Tracers
