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Introduction to the Ultrasound Targeted Microbubble Destruction Technique
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Bioengenharia
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JoVE Journal Bioengenharia
Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

DOI:
10.3791/2963-v

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08:24 min

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June 12, 2011

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, , ,
1Department of Medicine, JABSOM,University of Hawaii

Capítulos

  • 00:05Título
  • 01:44Microbubble Preparation
  • 02:48Equipment Calibration
  • 03:42Microbubble Delivery and UTMD
  • 06:23Bioluminescence Analysis of UTMD

Summary

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Ultrasound Targeted Microbubble Destruction (UTMD) can be used to direct site-specific delivery of bioactive molecules, including therapeutic genes, to target organs accessible to ultrasound, such as the heart and liver1-6.

Tags

Ultrasound Targeted Microbubble Destruction TechniqueUTMDBioactive MoleculesPlasmid DNA VectorsLipid Microbubble Contrast AgentsAcoustic CavitationResonant FrequencySonoporation EffectTransfection EfficiencyEndothelial CellsTransgene-encoding VectorsSpecific Target-organ Transfection

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