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Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice
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JoVE Journal Medicina
Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice

Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice

DOI:
10.3791/2968-v

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05:55 min

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October 03, 2011

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, , , , ,
1Department of Molecular Microbiology and Immunology, Bond Life Sciences Center,University of Missouri, 2Department of Biological Sciences,Columbia University , 3Department of Veterinary Pathobiology, Bond Life Sciences Center,University of Missouri

Capítulos

  • 00:05Título
  • 01:10Intracerebroventicular Injection
  • 03:45Intravenous Injection via the Temporal/Facial Vein
  • 05:28Conclusion

Summary

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This article demonstrates two very different methods of injection: 1) into the brain (intracerebroventricular) and 2) systemic (intravenous) to introduce the therapeutic agents into the central nervous system of neonatal mice.

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Intracerebroventricular InjectionIntravenous InjectionTherapeutic AgentsBlood Brain BarrierCentral Nervous SystemNeurodegenerative DisordersSpinal Muscular AtrophyNeonatal MiceCerebral Lateral VentriclesCerebrospinal FluidTemporal Vein InjectionViral VectorViral SerotypeSystemic DeliveryPermeable Blood Brain Barrier

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