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植入小鼠触发剪应力致动脉粥样硬化的颈袖

JoVE Journal
Medicina

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JoVE Journal Medicina

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

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植入小鼠触发剪应力致动脉粥样硬化的颈袖

DOI:

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07:51 min

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January 13, 2012

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Michael T. Kuhlmann, Simon Cuhlmann³, Irmgard Hoppe, Rob Krams, Paul C. Evans, Gustav J. Strijkers, Klaas Nicolay, Sven Hermann, Michael Schäfers

¹European Institute for Molecular Imaging,Westfälische Wilhelms-University Münster, ²British Heart Foundation Cardiovascular Sciences Unit,Imperial College London , ³Department of Bioengineering,Imperial College London , ⁴Biomedical Engineering,Eindhoven University of Technology

Capítulos

00:05Título
01:09Preparing the Shear Stress Modifier
01:59Implanting the Cuff Around the Right Carotid Artery
06:35Results: Shear Stress
07:33Conclusion

Summary

Tadução automática

本文介绍的收缩袖口的设计，以诱导小鼠左颈总动脉粥样硬化。由于其内腔的圆锥形植入袖口产生良好定义的低，高和振荡剪切引发动脉粥样硬化病变的不同炎症表型的发展压力的地区。

Tags

Carotid Cuff Shear Stress Atherosclerosis Inflammatory Genes Endothelial Cells Flow Dynamics Small Animal Models Plaque Development Carotid Artery Ligation Endothelial Dysfunction Atherosclerotic Lesions Shear Stress Modifying Cuff Fluid Dynamics Defined Regions Of Shear Stress Common Carotid Artery Apolipoprotein E (ApoE) Knockout Mice High Cholesterol Diet

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