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MRI引导下的破坏血脑屏障在大鼠模型经颅聚焦超声

JoVE Journal
Medicina

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JoVE Journal Medicina

MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model

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MRI引导下的破坏血脑屏障在大鼠模型经颅聚焦超声

DOI:

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07:42 min

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March 13, 2012

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Meaghan A. O’Reilly, Adam C. Waspe², Rajiv Chopra², Kullervo Hynynen³

¹Imaging Research,Sunnybrook Research Institute, ²Department of Medical Biophysics,University of Toronto, ³Department of Medical Biophysics, and Institute of Biomaterials & Biomedical Engineering (IBBME),University of Toronto

Capítulos

00:05Título
01:37Ultrasound and MRI Setup
02:08Animal Preparation
03:19Target Selection
03:45Microbubble Preparation
04:41Ultrasound Delivery
05:11MRI Evaluation of Treatment Outcome
05:45Delivery of MRI Contrast Agents Using Focused Ultrasound (FUS) and Circulating Microbubbles
07:17Conclusion

Summary

Tadução automática

微泡介导的重点超声破坏血脑屏障（BBB）的是一个很有前途的技术，针对大脑中的非侵入性给药<sup> 1-3</sup>。该协议概述MRI引导下经颅血脑屏障破坏大鼠模型的实验过程。

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