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Capítulos
- 00:05Título
- 01:43Intravenous Injection of Ad-2D6 into the Opthalmic Sinus
- 02:31Mouse Liver Perfusion
- 04:20Isolation of Liver Lymphocytes
- 05:39Representative Liver Morphology and Histology in hCYP2D6-infected Mice
- 07:30T Cell Responsiveness in hCYP2D6-infected Mice
- 08:15Conclusion
Infektion af mus med en Adenovirus udtrykker den vigtigste humane autoantigenet cytochrom P450 2D6 (hCYP2D6) anerkendt af sera af patienter, der lider type 2 autoimmun hepatitis resultater i en vedvarende form af autoimmun-medieret leversygdom kendetegnet af omfattende hepatitis, fibrose og generering af en CYP2D6 -specifikt immunrespons.
Tags
CYP2D6Animal ModelAutoimmune HepatitisMiceInductionLife ThreateningLiverAutoimmune DiseaseEtiologyHuman DiseaseMouse ModelAutoantigenAIH-2HCYP2D6TriggerLiver-kidney Microsomal AntibodiesLKM-1 AntibodiesAdenovirus ConstructLocal InflammationAutoimmunityIntravenous InjectionIntraperitoneal InjectionLong-lasting Autoimmune DamageLiver DiseaseProtocolHepatocyte DestructionAminotransferasesHCYP2D6 Antibodies
