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白色念珠菌生物膜芯片（CA BChip）为高通量的抗真菌药物筛选
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Bioengenharia
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JoVE Journal Bioengenharia
Candida albicans Biofilm Chip (CaBChip) for High-throughput Antifungal Drug Screening
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白色念珠菌生物膜芯片（CA BChip）为高通量的抗真菌药物筛选

DOI:
10.3791/3845-v

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08:05 min

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July 18, 2012

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, ,
1Department of Biomedical Engineering,University of Texas at San Antonio , 2Department of Biology,University of Texas at San Antonio

Capítulos

  • 00:05Título
  • 01:08Preparation of Functionalized Slides
  • 02:30Preparation of Yeast Inocula and Collagen Encapsulation
  • 03:40Preparation of CaBChip
  • 04:57Susceptibility Testing of Preformed Biofilms in CaBChip against Antifungal Agents
  • 06:38Representative Biofilm Chip Results
  • 07:48Conclusion

Summary

Tadução automática

Tadução automática

我们已经开发出一种高密度芯片平台的3D纳米生物膜的组成<em> C。白念珠菌</em>称为<em>钙</em> BChip。上测试药物的敏感性个人资料<em>钙</em> BChip是传统的96孔板模式相媲美，表明真菌的芯片非常适合真正的高通量筛选抗真菌药物。

Tags

Candida AlbicansBiofilm ChipCaBChipHigh-throughputAntifungal Drug ScreeningCandidiasisNosocomial Bloodstream InfectionCompromised IndividualsMortality RatesAntifungal DrugsResistanceBiofilmsMicroarrayC. Albicans Nano-biofilmsRobotic MicroarrayerYeast CellsSolid SubstrateThree-dimensional MatrixGlass SubstrateCoatingIncubationPhenotypic Characteristics

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