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Capítulos
- 00:05Título
- 01:23Induction of Anesthesia
- 02:49Thoracotomy and Heart Preparation
- 04:16Coronary Artery Instrumentation
- 05:19Chest Closure and Myocardial Ischemia and Reperfusion
- 06:56Infarct Size Assessment with Reperfusion Time up to 3 Days
- 09:38Alternative Heart Preparation for Histology
- 11:09Results: The Murine Chronic Closed-chest Model Allows a More Lifelike Approach to Myocardial Ischemia and Reperfusion
- 13:19Conclusion
Kirurgiskt trauma inducerar en inflammatorisk reaktion. Cytokiner och endogena ligander är kända för att modulera myokardinfarktstorlek efter ischemi och reperfusion. Vi presenterar en modifierad sluten kista modell av murin ischemi och reperfusion med hängande vikter för att minimera effekterna av torakotomi.
Tags
Murine Closed-chest ModelMyocardial IschemiaReperfusionSurgical TraumaThoracotomyImmune ResponseCytokine ExpressionEndogenous LigandsInnate ImmunityInfarct SizeMyocardial Pre- And PostconditioningHanging WeightsVolatile AnestheticsPreconditioning EffectChronic Closed-chest ModelIntermittent IschemiaMultiple Hit ModelsIntubated MiceVentilated MiceLateral Blunt ThoracotomyLeft Anterior Descending Ligation
