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Utilisation de la souris BLT humanisé comme une tumeur de cellules souches Gene Therapy modèle basé sur
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1Department of Medicine, Division of Hematology-Oncology,David Geffen School of Medicine at UCLA, 2UCLA AIDS Institute, 3Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, 4Department of Medical and Molecular Pharmacology,David Geffen School of Medicine at UCLA, 5Department of Microbiology, Immunology and Molecular Genetics,David Geffen School of Medicine at UCLA
Capítulos
- 00:05Título
- 01:26Tissue Transplantation
- 05:27Results: PET Imaging Is a More Sensitive and Accurate Way to Assess Tumor Regression and Clearance
- 06:41Conclusion
La génération et la caractérisation des tumeurs des cellules T spécifiques en utilisant des souris humanisés est décrit ici. Human tissu thymique et génétiquement modifiés cellules souches hématopoïétiques humaines sont transplantées dans des souris immunodéprimées. Cela se traduit par la reconstitution d'un système immunitaire humain ingénierie permettant l'examen in vivo des réponses anti-tumorales immunitaires.
Tags
BLT Humanized MouseStem Cell-based Gene TherapyTumor ModelSmall Animal ModelsMiceHuman DiseaseTherapeutic InterventionsMouse ImmunityViral DiseasesHuman Immunodeficiency Virus (HIV) InfectionHumanized Mouse ModelsC. B 17 Scid/scid MiceHuman Fetal ThymusFetal LiverThy/liv (SCID-hu)Adoptive Transfer Of Human Peripheral Blood Leukocytes (SCID-huPBL)Physiologically Relevant ModelBLT Stands For Bone Marrow/liver/thymusNOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) Immunocompromised MiceHuman Hematopoietic Stem Cell TransplantHIV Infection And Latency
