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Uso del ratón humanizado BLT como un modelo de células madre del tumor Terapia génica basada en
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1Department of Medicine, Division of Hematology-Oncology,David Geffen School of Medicine at UCLA, 2UCLA AIDS Institute, 3Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, 4Department of Medical and Molecular Pharmacology,David Geffen School of Medicine at UCLA, 5Department of Microbiology, Immunology and Molecular Genetics,David Geffen School of Medicine at UCLA
Capítulos
- 00:05Título
- 01:26Tissue Transplantation
- 05:27Results: PET Imaging Is a More Sensitive and Accurate Way to Assess Tumor Regression and Clearance
- 06:41Conclusion
La generación y caracterización de células T específicas de tumor en ratones humanizados se describe aquí. Tejido del timo humano y genéticamente modificados células madre hematopoyéticas son trasplantados en ratones inmunodeficientes. Esto da como resultado la reconstitución de una ingeniería del sistema inmune humano permitiendo examen in vivo de anti-tumor de la respuesta inmune.
Tags
BLT Humanized MouseStem Cell-based Gene TherapyTumor ModelSmall Animal ModelsMiceHuman DiseaseTherapeutic InterventionsMouse ImmunityViral DiseasesHuman Immunodeficiency Virus (HIV) InfectionHumanized Mouse ModelsC. B 17 Scid/scid MiceHuman Fetal ThymusFetal LiverThy/liv (SCID-hu)Adoptive Transfer Of Human Peripheral Blood Leukocytes (SCID-huPBL)Physiologically Relevant ModelBLT Stands For Bone Marrow/liver/thymusNOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) Immunocompromised MiceHuman Hematopoietic Stem Cell TransplantHIV Infection And Latency
