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Surgical Technique for Spinal Cord Delivery of Therapies: Demonstration of Procedure in Gottingen Minipigs
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JoVE Journal Medicina
Surgical Technique for Spinal Cord Delivery of Therapies: Demonstration of Procedure in Gottingen Minipigs

Surgical Technique for Spinal Cord Delivery of Therapies: Demonstration of Procedure in Gottingen Minipigs

DOI:
10.3791/4371-v

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09:23 min

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December 07, 2012

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, , , , , , , , , ,
1Department of Neurosurgery,Emory University, 2Department of Neuroscience,Medical University of South Carolina, 3Division of Neurosurgery,University of Alabama, Birmingham, 4Department of Biomedical Engineering,Georgia Institute of Technology , 5Department of Biomedical Engineering,Emory University

Capítulos

  • 00:05Título
  • 01:55Animal Use, Anesthesia, and Positioning
  • 03:26Laminectomy, Placement of Spinal Derrick, and Assembling a Floating Cannula
  • 05:17Opening the Dura and Spinal Cord Injections, and Closure
  • 08:16Representative Spinal Cord Delivery Results
  • 09:00Conclusion

Summary

Tadução automática

Tadução automática

Short visual description of the surgical technique and device used for the delivery of (gene and cell) therapies into the spinal cord. The technique is demonstrated in the animal but is entirely translatable and currently being used for human application.

Tags

Surgical TechniqueSpinal Cord DeliveryTherapiesDemonstration Of ProcedureGottingen MinipigsGene TherapiesCell TherapiesStem Cell TransplantationFDA-approvedALS PatientsProof-of-principle DataRodent ModelsLarge AnimalsSurgical ProcedureDevice SafetyHuman UseSwine ModelProcedural Safety

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