É necessária uma assinatura da JoVE para visualizar este conteúdo. Faça login ou comece sua avaliação gratuita.
Capítulos
- 00:05Título
- 01:51Generation of Zebrafish with Diabetes Mellitus
- 04:26Blood Collection and Fasting Blood Glucose Level (FBGL) Determination
- 05:51Caudil Fin Regeneration
- 07:17Generation of Metabolic Memory Zebrafish
- 08:46Representative Fin Regeneration Results
- 09:38Conclusion
Metabolic memory is the phenomenon by which diabetic complications persist and progress unimpeded even after euglycemia is achieved pharmaceutically. Here we describe a diabetes mellitus zebrafish model which is unique in that it allows for the examination of the mitotically transmissible epigenetic components of metabolic memory in vivo.
