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Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies
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Medicina
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JoVE Journal Medicina
Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies

Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies

DOI:
10.3791/50370-v

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08:40 min

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June 09, 2013

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,
1Department of Neuroscience,University of Turin , 2Neuroscience Institute of Turin (NIT),University of Turin , 3Neuroscience Institute Cavalieri-Ottolenghi (NICO),University of Turin , 4Department of Anatomy, Pharmacology and Forensic Medicine,University of Turin

Capítulos

  • 00:01Título
  • 01:09Introduction
  • 01:54Preparation
  • 02:30Tool presentation
  • 03:12Anesthesia procedure
  • 04:05Surgery for illumination of the targeted area
  • 05:44Rose Bengal injection and activation
  • 06:20Suture
  • 07:06Representative results
  • 07:55Conclusion

Summary

Tadução automática

Tadução automática

Photothrombosis is a quick, minimally-invasive technique for inducing small and well-delimited infarction in areas of interest in highly reproducible manner. It is particularly suitable for studying cellular and molecular responses underlying brain plasticity in transgenic mice.

Tags

Photothrombotic IschemiaPhotochemical Cortical LesionMouse Stroke ModelRose BengalEndothelial DamagePlatelet ActivationThrombosisNon-invasiveReproducibleTransgenic MiceBrain Plasticity

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