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A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects
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JoVE Journal Medicina
A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects

A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects

DOI:
10.3791/50440-v

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07:00 min

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August 14, 2013

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, , ,
1Department of Ophthalmology,Northwestern University, 2Department of Neurobiology,Northwestern University

Capítulos

  • 00:05Título
  • 01:30Laser Photocoagulation
  • 03:11Intraocular Pressure Measurements
  • 04:02Optomotor Test
  • 05:24Results: Changes in Intraocular Pressure and Visual Acuity Following Laser Treatment
  • 06:16Conclusion

Summary

Tadução automática

Tadução automática

Chronic ocular hypertension is induced using laser photocoagulation of the trabecular meshwork in mouse eyes. The intraocular pressure (IOP) is elevated for several months after laser treatment. The decrease of visual acuity and contrast sensitivity of experimental animals are monitored using the optomotor test.

Tags

Laser-induced Ocular HypertensionMouse ModelGlaucomaIntraocular PressureVisual DefectsOptomotor TestContrast SensitivityNeuronal Degeneration

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