A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

Zuhaib Ibrahim; Damon S. Cooney; Jaimie T. Shores; Justin M. Sacks; Eric G. Wimmers; Steven C. Bonawitz; Chad Gordon; Dawn Ruben; Stefan Schneeberger; W. P. Andrew Lee; Gerald Brandacher

doi:10.3791/50475

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A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

JoVE Journal
Medicina

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JoVE Journal Medicina

A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

DOI:

10.3791/50475-v

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09:09 min

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October 14, 2013

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Zuhaib Ibrahim, Damon S. Cooney, Jaimie T. Shores, Justin M. Sacks, Eric G. Wimmers, Steven C. Bonawitz, Chad Gordon, Dawn Ruben, Stefan Schneeberger, W. P. Andrew Lee, Gerald Brandacher

¹Plastic and Reconstructive Surgery,Johns Hopkins University School of Medicine

Capítulos

00:05Título
02:06Osteomyocutaneous Limb Allograft Harvest from Donor Pig
04:23Recipient Hind Limb Allotransplantation
07:17Results: Vascularized Composite Allotransplantation
07:50Conclusion

Summary

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Vascularized Composite Allotransplantations (VCA) have become a clinical reality. However, broad clinical application of VCA is limited by chronic multi-drug immunosuppression. The authors present a reliable and reproducible large animal model to translate novel immunomodulatory strategies that can minimize or potentially eliminate the need of immunosuppression in VCA.

A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

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