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One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles
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1Department of Pharmaceutical Sciences,University of Toronto, 2The Institute of Biomaterials and Biomedical Engineering,University of Toronto, 3Ontario Cancer Institute,Campbell Family Institute For Cancer Research and Techna Institute, 4Department of Biomedical Engineering,University at Buffalo, The State University of New York
Capítulos
- 00:05Título
- 01:41Preparation of Porphysomes
- 05:27In vivo Photothermal Therapy
- 07:43Porphysome Characterization and Tumor Treatment Results
- 09:23Conclusion
We developed novel intrinsic multifunctional nanovesicles called porphysomes, which have structure-dependent fluorescence self-quenching and unique photothermal properties, thus functioning as potent photothermal therapy agents. We formulated porphysomes using high pressure extrusion and investigated their photothermal therapy efficacy in a xenograft tumor model.
Tags
PorphysomesPhotothermal Tumor AblationIntrinsic Multifunctional NanovesiclesPhotosensitizerPyropheophorbide αPhospholipidLiposome-like Spherical VesiclesExtinction CoefficientsFluorescence Self-quenchingPhotothermal EfficacyHigh Pressure ExtrusionTumor Temperature IncreaseLaser IrradiationThermal AblationEscharsPhotothermal Therapy (PTT)
