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酪氨酸激酶抑制剂的临床前评价急性白血病的治疗

JoVE Journal
Medicina

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JoVE Journal Medicina

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

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酪氨酸激酶抑制剂的临床前评价急性白血病的治疗

DOI:

10.3791/50720-v

•

10:49 min

•

September 18, 2013

•

Sandra Christoph², Alisa B. Lee-Sherick, Susan Sather, Deborah DeRyckere, Douglas K. Graham

¹Department of Pediatrics,University of Colorado Anschutz Medical Campus, ²Department of Bone Marrow Transplantation,University Hospital of Essen

Capítulos

00:05Título
01:39Phospho-protein Western Blot
03:02Methylcellulose Assay
04:24Evaluation of Phospho-protein Inhibition in vivo
05:39Evaluation of Anti-leukemia Activity of TKIs in ALL Xenograft Models
08:13Results: Biochemical and Functional Effects Mediated by TKIs
10:07Conclusion

Summary

Tadução automática

受体酪氨酸激酶是异位表达在许多癌症和已被确定为在急性白血病的治疗靶点。此手稿描述为酪氨酸激酶抑制剂对急性白血病的治疗的临床前评价的有效策略。

Tags

Keywords: Tyrosine Kinase Inhibitors Acute Leukemia Pre-clinical Evaluation Receptor Tyrosine Kinases NOD-SCID-gamma Mice Bioluminescence Imaging Clonogenic Assays Pharmacodynamics Target Inhibition

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