/
/
A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
É necessária uma assinatura da JoVE para visualizar este conteúdo. Faça login ou comece sua avaliação gratuita.
1Research Center on Aging and Department of Physiology and Biophysics,Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center,Université de Sherbrooke, 3Department of Computer Science,Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology,Université de Sherbrooke
Capítulos
- 00:05Título
- 02:19Brain Anatomy with MRI
- 03:19Dual Tracer PET Acquisitions
- 08:29Quantitative PET Analysis
- 12:56Results: Dual Tracer PET-MRI
- 14:00Conclusion
Small-animal positron emission tomography enables the assessment of the brain's two main energy substrates: glucose and ketones. In the present method, 11C-acetoacetate and 18F-fluorodeoxyglucose are injected sequentially in each animal, and their uptake is measured quantitatively in specific brain regions determined from the magnetic resonance images.
