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方法对NF-κB依赖的成年神经发生的调制与分析

JoVE Journal
Neurociência

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JoVE Journal Neurociência

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

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方法对NF-κB依赖的成年神经发生的调制与分析

DOI:

10.3791/50870-v

•

14:58 min

•

February 13, 2014

•

Darius Widera, Janine Müller, Yvonne Imielski, Peter Heimann, Christian Kaltschmidt, Barbara Kaltschmidt

¹Cell Biology,University of Bielefeld, ²Molecular Neurobiology,University of Bielefeld

Capítulos

00:05Título
02:19Preparing the Spatial Pattern Separation-Barnes Maze
04:27Running the Spatial Pattern Separation-Barnes Maze
06:15Sectioning the Perfused Animals and Investing the Mossy Fiber Projections
08:41Neurodegeneration and Behavioral Defects from IκBα Expression via CAMKIIα Promoter Control
14:22Conclusion

Summary

Tadução automática

方法的NF-κB依赖型成年海马神经发生的操作和分析的描述。详细的协议提出了一个齿状回依赖性行为测试（称为空间格局分离巴恩斯迷宫）的认知结果小鼠的调查。这项技术也将有助于使在其他实验设置的调查。

Tags

NF-κB Adult Neurogenesis Hippocampus Dentate Gyrus Spatial Pattern Separation Barnes Maze Transgenic Mouse Model Neuronal Plasticity

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