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An Orthotopic Glioblastoma Mouse Model Maintaining Brain Parenchymal Physical Constraints and Suitable for Intravital Two-photon Microscopy
 

An Orthotopic Glioblastoma Mouse Model Maintaining Brain Parenchymal Physical Constraints and Suitable for Intravital Two-photon Microscopy

Article DOI: 10.3791/51108-v • 09:52 min • April 21st, 2014
April 21st, 2014 •
1,2, 1,3, 1,2, 1,2
1Developmental Biology Institute of Marseille, Aix Marseille University, 2European Research Center for Medical Imaging, Campus de la Timone, 3Vesalius Research Center, KU Leuven Campus Gasthuisberg

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We have established a cortical orthotopic glioblastoma model in mice for intravital two-photon microscopy that recapitulates the biophysical constraints normally at play during the growth of the tumor. A chronic glass window replacing the skull above the tumor enables the follow-up of the tumor progression over time by two-photon microscopy.

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Keywords: Glioblastoma Mouse Model Orthotopic Two-photon Microscopy Brain Parenchyma Tumor Spheroid Dextran Gel Craniotomy Fluorescent Transgenic Intravital Imaging Neuro-oncology Drug Testing
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