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Capítulos
- 00:05Título
- 01:08Preparation of Microslices
- 02:27Equilibration of Microslices
- 03:46Excitotoxic Stimulation
- 05:26Results: Viability of Microslices
- 06:41Conclusion
We have developed a brain slice model which can be used to examine molecular mechanisms involved in excitotoxicity-mediated brain injury. This technique generates viable mature brain tissue and reduces animal numbers required for experimentation, whilst keeping the neuronal circuitry, cellular interactions, and postsynaptic compartments partly intact.
