/
/
Methods to Characterize Spontaneous and Startle-induced Locomotion in a Rotenone-induced Parkinson’s Disease Model of Drosophila
É necessária uma assinatura da JoVE para visualizar este conteúdo. Faça login ou comece sua avaliação gratuita.
Capítulos
- 00:05Título
- 01:12Startle-induced Locomotion Assay and Setup
- 03:11Startle-induced Locomotion Experimentation and Data Analysis
- 04:04Spontaneous Locomotion Assay Setup
- 05:19Spontaneous Locomotion Data Collection and Analysis
- 06:36Results: Rotenone-induced Response Deficiency
- 07:35Conclusion
Parkinson’s disease is a neurodegenerative disorder that results from the degeneration of dopaminergic neurons in the central nervous system, causing locomotion defects. Rotenone models Parkinson’s disease in Drosophila. This paper outlines two assays that characterize both spontaneous and startle-induced locomotion deficiencies caused by rotenone.
