Journal
/
/
Vasculaire Transfert de gènes à partir de stent métallique surfaces à l'aide vecteurs adénoviraux Tethered par hydrolysables de la Croix-linkers
JoVE Journal
Medicina
É necessária uma assinatura da JoVE para visualizar este conteúdo.  Faça login ou comece sua avaliação gratuita.
JoVE Journal Medicina
Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
DOI:

12:30 min

August 12, 2014

, , , , ,

Capítulos

  • 00:05Título
  • 01:51Ad-eluting Stent Deployment in the Rat Carotid Model of Stent Angioplasty
  • 05:37Bioluminescence Imaging of Arterial Gene Expression
  • 09:00Systemic Administration of Luciferin
  • 09:55Representative Bioluminescence Imaging Following Placement of AdLUC-eluting Stents
  • 11:46Conclusion

Summary

Tadução automática

These studies report on reversible attachment of adenoviral gene vectors to coatless metal surfaces of stents and model mesh disks. Sustained release of transduction-competent viral particles contingent upon hydrolysis of cross-linkers used for vector immobilization results in a durable site-specific transgene expression in vascular cells and in stented arteries.

Vídeos Relacionados

Read Article