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Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch
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JoVE Journal Medicina
Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch

Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch

DOI:
10.3791/52403-v

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07:05 min

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February 10, 2015

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, , ,
1Department of Biomedical Engineering,University of Texas at Austin

Capítulos

  • 00:05Título
  • 01:24Femoral Artery Isolation
  • 03:00Femoral Artery Wire Injury, Arterial Closure, and Perivascular Drug Patch Implantation
  • 05:53Results: Representative Histological Results at 14 days Post Wire Injury
  • 06:26Conclusion

Summary

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Tadução automática

We describe a surgical technique that produces wire injury in the femoral artery of mice to induce neointimal hyperplasia to serve as a model testing system for the perivascular delivery of therapeutic compounds for the inhibition of restenosis.

Tags

Keywords: Murine ModelFemoral ArteryWire InjuryPerivascular Drug DeliveryPercutaneous InterventionRestenosisIntimal HyperplasiaVascular Smooth Muscle CellsInflammationArterial StretchArteriotomyEndothelial DenudationNeointimal HyperplasiaDegradable Drug Delivery Patch

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