Desenvolvimento de inibidores de interacções proteína-proteína através REPLACE: Aplicação para a concepção e desenvolvimento não-ATP inibidores de CDK Competitiva
Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
We describe implementation of the REPLACE strategy for targeting protein-protein interactions. REPLACE is an iterative strategy involving synthetic and computational approaches for the conversion of optimized peptidic inhibitors into drug like molecules.