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Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect
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JoVE Journal Medicina
Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect

Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect

DOI:
10.3791/52618-v

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07:38 min

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June 14, 2015

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, ,
1Department of Physiology & Cell Biology, Davis Heart and Lung Research Institute,The Ohio State University, 2Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology

Capítulos

  • 00:05Título
  • 01:07Carotid Artery Catherization
  • 03:14Bowditch Effect
  • 04:09Generating the End Systolic Pressure Volume Relationship, the Preload Recruitable Stroke Work, and Volume Calibration
  • 05:43Results: The Bowditch Effect in Catheterized Mice
  • 07:14Conclusion

Summary

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This article describes the measurement of murine left ventricular function via pressure/volume analysis at different heart rates.

Tags

Keywords: Cardiac CatheterizationMicePressure Volume RelationshipBowditch EffectLeft Ventricular FunctionContractilityHeart Rate+dP/dt-dP/dtEnd Systolic Pressure Volume RelationshipPreload Recruitable Stroke WorkCardiomyopathyNeuronal Nitric Oxide Synthase (NOS1) Knockout

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