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A Method to Inflict Closed Head Traumatic Brain Injury in Drosophila
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Neurociência
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JoVE Journal Neurociência
A Method to Inflict Closed Head Traumatic Brain Injury in Drosophila

A Method to Inflict Closed Head Traumatic Brain Injury in Drosophila

DOI:
10.3791/52905-v

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05:22 min

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June 30, 2015

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, , , , ,
1Department of Cell and Regenerative Biology,University of Wisconsin-Madison, 2Department of Genetics,University of Wisconsin-Madison, 3Department of Natural Sciences,University of Puerto Rico-Aguadilla

Capítulos

  • 00:05Título
  • 01:08Construction of a High Impact Trauma Device
  • 02:32High Impact Trauma Device Operation
  • 04:17Results: Primary Injury Severity Correlates with the Mortality Index at 24 hr
  • 05:01Conclusion

Summary

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Here we describe a method to inflict closed head traumatic brain injury (TBI) in Drosophila. This method provides a gateway to investigate the cellular and molecular mechanisms that underlie TBI pathologies using the vast array of experimental tools and techniques available for flies.

Tags

Traumatic Brain InjuryDrosophilaHigh Impact Trauma (HIT) DeviceClosed Head InjuryNeurodegenerationGenetic Screening

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