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Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function
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JoVE Journal Medicina
Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function

Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function

DOI:
10.3791/53758-v

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11:47 min

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January 22, 2017

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, , , , , , , , ,
1Neuroscience Program,Skidmore College, 2Chemistry Department,Skidmore College, 3Health and Exercise Science Department,Skidmore College

Capítulos

  • 00:05Título
  • 01:25Footprint Analysis
  • 03:00Beam Analysis
  • 04:16Accelerating Rotarod
  • 05:35Immunopathology Assay
  • 09:39Results: Treatment Scheme and Representative Data from the Footprint Assay, Beam Assay and Accelerating Rotarod
  • 10:59Conclusion

Summary

Tadução automática

Tadução automática

We present a biochemical and behavioral protocol to evaluate the efficacy of mitochondria-targeted water-soluble compounds for the treatment of Spinocerebellar ataxia type 1 (SCA1) and other cerebellar neurodegenerative diseases.

Tags

SCA1Mitochondrial FunctionWater-soluble CompoundsNeurodegenerative DiseasesBehavioral ParadigmsFootprint TestBeam Apparatus

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