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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

DOI:
10.3791/53785-v

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07:44 min

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April 24, 2016

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, ,
1Department of Biochemistry and Molecular Biology,Louisiana State University Health Sciences Center, 2Molecular Physiology and Therapeutics Branch,National Institute of Dental and Craniofacial Research, NIH, DHHS

Capítulos

  • 00:05Título
  • 00:52Submandibular Salivary Gland Cannulation
  • 03:32Submandibular Gland Instillation
  • 04:40Submandibular Gland Localized Fractionated Irradiation
  • 05:35Results: Representative Effect of Fractionated Radiation on Submandibular Gland Function
  • 06:34Conclusion

Summary

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Tadução automática

Salivary gland hypofunction, a major adverse effect of head and neck radiotherapy diminishes a patient's quality of life. The demonstration of efficacy of new therapies in animal models is a prerequisite before clinical transition. This protocol describes retroductal administration and local irradiation of rat submandibular glands.

Tags

Keywords: Retroductal Submandibular Gland InstillationLocalized Fractionated IrradiationRat ModelSalivary HypofunctionSalivary Gland DisordersSalivary Gland FunctionRadiationTargeted TherapyPE 10 Polyethylene TubingInsulin SyringeSedationRestraining PlatformTongueSublingual PapilliCannula

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