Journal
/
Química
/
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
JoVE Journal
Química
É necessária uma assinatura da JoVE para visualizar este conteúdo.  Faça login ou comece sua avaliação gratuita.
JoVE Journal Química
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

DOI:
10.3791/53789-v

•

08:43 min

•

January 19, 2016

•

,
1Department of Chemistry,State University of New York at Stony Brook, 2Institute of Chemical Biology and Drug Discovery,State University of New York at Stony Brook

Capítulos

  • 00:05Título
  • 00:53Precursor Preparation: Synthesis of Methyl 4-(N-hydroxyacetamido) Benzoate
  • 04:33Synthesis of Methyl 4-(N-trifluoromethoxy)acetamido) Benzoate
  • 05:58Synthesis of Methyl 4-Acetamido-3-(trifluoromethoxy) Benzoate via Trifluoromethoxy-migration
  • 07:14Results: Synthesis of Trifluoromethoxylated Aniline Derivatives Using Togni Reagent II
  • 08:12Conclusion

Summary

Tadução automática

Tadução automática

An operationally simple procedure for the synthesis of ortho-trifluoromethoxylated aniline derivatives via a two-step sequence of O-trifluoromethylation of N-aryl-N-hydroxyacetamide followed by thermally induced intramolecular OCF3-migration is reported.

Tags

Keywords: Ortho-trifluoromethoxylated AnilineAniline DerivativesReductionHydrogenationAcetyl ProtectionRhodium CatalystCelite FiltrationTLC MonitoringAnhydrous SolventsNitrogen Atmosphere

Article

Embed

ADICIONAR À PLAYLIST

Usage Statistics

Vídeos Relacionados

check_url/pt/53789?article_type=v

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
check_url/pt/53789?article_type=v

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
check_url/pt/53789?article_type=v

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
check_url/pt/53789?article_type=v

Facile Preparation of 4-Substituted Quinazoline Derivatives
check_url/pt/53789?article_type=v

A Protocol for the Production of Gliadin-cyanoacrylate Nanoparticles for Hydrophilic Coating
check_url/pt/53789?article_type=v

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
check_url/pt/53789?article_type=v

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
check_url/pt/53789?article_type=v

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2′-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
check_url/pt/53789?article_type=v

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
check_url/pt/53789?article_type=v

The MPLEx Protocol for Multi-omic Analyses of Soil Samples

Read Article