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Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema
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Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

DOI:
10.3791/54170-v

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08:44 min

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September 01, 2016

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, ,
1Neurotrauma Research,Swedish Medical Center, 2Neurosurgery,Colorado Brain and Spine Institute

Capítulos

  • 00:05Título
  • 00:48In Vivo Stroke Induction
  • 03:06Neurological Deficit Scoring (NDS) and Filament Removal
  • 04:14Intravenous Catheter Jugular Vein Installation for Continuous 48 Hr Treatment
  • 06:28Results: Representative Effects of Continuous I.V. or I.P. Conivaptan Treatment on Stroke-evoked Brain Edema
  • 07:18Conclusion

Summary

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Tadução automática

Our studies have revealed that the beneficial effects of conivaptan are dependent on the method of delivery after experimental stroke in mice. We have developed a research protocol for delivery of the receptor blocker via IV catheter on stroke-evoked brain edema formation in mice.

Tags

Keywords: IV InfusionArginine-vasopressin Receptor BlockerConivaptanMouse ModelStrokeBrain EdemaDelivery RoutePre-clinical StudyNylon SutureDental ResinCarotid ArteryMicrovascular ClipBupivacaine

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