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1Department of Surgery,University of Maryland School of Medicine, 2Department of Medicine,University of Maryland School of Medicine, 3Department of Radiology,University of Maryland School of Medicine, 4Food and Drug Administration, 5Department of Pharmaceutical Sciences,University of Maryland School of Pharmacy, 6VA Maryland Health Care System
Capítulos
- 00:05Título
- 00:5919F-Labeled Bile Acid Gavage, Organ Harvest and Bile Acid Measurement
- 04:02Live Animal Proton (1H) and Fluorine (19F) Magnetic Resonance Imaging (MRI)
- 05:51Results: Representative Multi-fluorinated Bile Acid (MFBA) Measurement in the Mouse Gallbladder
- 07:51Conclusion
Outils pour diagnostiquer la bile malabsorption d'acide et de mesurer le transport des acides biliaires in vivo sont limitées. Une approche innovante d'animaux vivants est décrit qui utilise des protons combiné (1 H) plus de fluor (19 F) d'imagerie par résonance magnétique; cette nouvelle méthodologie a un potentiel de translation à l'écran pour malabsorption des acides biliaires dans la pratique clinique.
