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1Department of Surgery,University of Maryland School of Medicine, 2Department of Medicine,University of Maryland School of Medicine, 3Department of Radiology,University of Maryland School of Medicine, 4Food and Drug Administration, 5Department of Pharmaceutical Sciences,University of Maryland School of Pharmacy, 6VA Maryland Health Care System
Capítulos
- 00:05Título
- 00:5919F-Labeled Bile Acid Gavage, Organ Harvest and Bile Acid Measurement
- 04:02Live Animal Proton (1H) and Fluorine (19F) Magnetic Resonance Imaging (MRI)
- 05:51Results: Representative Multi-fluorinated Bile Acid (MFBA) Measurement in the Mouse Gallbladder
- 07:51Conclusion
Verktyg för att diagnostisera gallsyremalabsorption och mäta gallsyratransporten in vivo är begränsade. En innovativ strategi i levande djur beskrivs som utnyttjar kombinerad proton (1H) plus fluor (19 F) magnetisk resonanstomografi; denna nya metod har translationell potential att screena för gallsyremalabsorption i klinisk praxis.
