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Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

JoVE Journal
Bioquímica

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JoVE Journal Bioquímica

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

DOI:

10.3791/54873-v

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09:45 min

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April 27, 2017

•

Tobias G. Kapp*¹, Maximilian Fottner*¹, Horst Kessler

¹Department of Chemistry,Technische Universität München

Capítulos

00:05Título
00:59Synthesis of the Guanidinylation Precursors: Methylated Species
02:30Synthesis of the Guanidinylation Precursors: Hexylamine-modified Species
03:55Synthesis of the Guanidinylation Precursors: Acylated Species
06:31Guanidinylation and Deprotection in Solution
08:14Results: Synthesis of Alkyl-modified Guanidines
09:11Conclusion

Summary

Tadução automática

A protocol for the synthesis of alkyl-modified guanidines based on the use of the corresponding precursors is presented.

Tags

Keywords: Guanidine Functionalization Peptides Integrin Ligands GPCR Ligands SPPS Molecular Imaging Personalized Medicine Boc-pyrazol Carboxamaidine PPh3 THF Methanol Diisopropyl Azodicarboxylate DCM Silica Column Dde-6-Aminohexanol

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