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A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice
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Medicina
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JoVE Journal Medicina
A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice

A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice

DOI:
10.3791/54988-v

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07:59 min

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June 18, 2017

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, , , , ,
1Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman and Campbell Brain and Spine,Indiana University School of Medicine, 2Norton Neuroscience Institute,Norton Healthcare, 3Department of Anatomical Sciences and Neurobiology,University of Louisville

Capítulos

  • 00:05Título
  • 01:13Animal Preparation and T10 Spinal Laminectomy
  • 03:06T10 Contusion Injury Using the LISA Impactor
  • 06:13Results: Histologic Assessment of T10 Contusion Injury
  • 07:07Conclusion

Summary

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We introduce a tissue displacement-based contusive spinal cord injury model that can produce a consistent contusive spinal cord injury in adult mice.

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Contusive Spinal Cord InjuryMouse ModelC57BL6J MiceKetamineXylazineBuprenorphineCarprofenBetadineAlcohol WipesOphthalmic OintmentSkin IncisionParaspinal MusclesAgricola RetractorT10 VertebraRongeurDura MaterImpactor

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