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Immunology and Infection

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JoVE Journal Immunology and Infection
Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
 

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent

Article DOI: 10.3791/55180-v • 06:46 min • May 8th, 2017
May 8th, 2017 •
1,2, 1, 1,3, 1, 1
1Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, 2Department of Nuclear Medicine, Eberhard Karls University of Tübingen, 3Department of Dermatology, Eberhard Karls University of Tübingen

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This paper explains the application of fluorescent imaging using an activatable optical imaging probe to visualize the in vivo activity of key matrix metalloproteinases in two different experimental models of inflammation.

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Non-invasive In Vivo Fluorescence Optical Imaging Inflammatory MMP Activity Activatable Fluorescent Imaging Agent Biological Mechanism Inflammatory Diseases Fast Cheap Easy To Learn Probes Rheumatoid Arthritis Induction Micrometer Ankle Diameters Mouse Serum Antibodies Glucose Six Phosphate Isomerase GPI Ankle Swelling Contact Hypersensitivity Sensitization Animal Hair Trimmer Abdomen Area Anesthetized Mouse TNCB Solution
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