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1Department of Anesthesiology,Ohio State University College of Medicine, 2Department of Anesthesiology and Pain Medicine,Nationwide Children’s Hospital, 3Department of Anaesthesia and Critical Care Medicine,University of Toronto, 4Department of Biomedical Sciences, Section of Anatomic Pathology,Cornell University College of Veterinary Medicine, 5Department of Pathology and Anatomy,Ohio State University College of Medicine, 6Department of Pathology and Laboratory Medicine,Nationwide Children’s Hospital
Capítulos
- 00:05Título
- 00:45Preparing the Animal
- 02:49Femoral Artery Catheterization
- 04:11Collecting Data and Completing Surgery
- 05:30Results: Consistency and Reproducibility of Lab Values
- 06:07Conclusion
A pesquisa de neurotoxicidade do desenvolvimento induzida por anestesia (AIDN) focalizou os roedores, que não são amplamente aplicáveis aos seres humanos. Os modelos de primatas não humanos são mais relevantes, mas são custo-proibitivos e difíceis de usar para a experimentação. O leitão, ao contrário, é um modelo animal clinicamente relevante, prático, ideal para o estudo da neurotoxicidade anestésica.
Tags
Keywords:
Piglet ModelAnesthetic-induced Developmental Neurotoxicity (AIDN)Translational NeurosciencePhysiologic HomeostasisAnesthesia InductionPulse OximetryBlood PressureElectrocardiographyTemperatureTracheal IntubationLidocaineEnd-tidal Carbon DioxideOphthalmic OintmentAntibioticSterile FieldFemoral Neurovascular Bundle
