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一次性充填机对治疗药物的肺吹入小动物

JoVE Journal
Medicina

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JoVE Journal Medicina

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

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一次性充填机对治疗药物的肺吹入小动物

DOI:

10.3791/55356-v

•

04:22 min

•

March 30, 2017

•

Phillip G. Durham, Shumaila N. Hanif, Lucia Garcia Contreras, Ellen F. Young, Miriam S. Braunstein, Anthony J. Hickey

¹RTI International, ²Oklahoma University Health Science Center, ³University of North Carolina at Chapel Hill

Capítulos

00:05Título
00:55Dosator Assembly, Filling and Actuation
02:39Results: Representative Pharmacokinetic Evaluation via Passive Inhalation
03:38Conclusion

Summary

Tadução automática

在药物对肺部给药的发展，有必要在动物模型来评价药代动力学和药效。我们呈现给从可以用于施用肺内干粉气雾剂到啮齿动物的现成组件构建的一次性气雾剂分散系统的方法。

Tags

Disposable Dosator Pulmonary Insufflation Therapeutic Agents Small Animals Dry Powder Aerosol Aerosol Dispersion System Aerosol Science Pharmacokinetics Efficacy Testing Polypropylene Microcentrifuge Tube Stainless Steel Wire Cloth Analytical Microbalance Syringe Dosing Port Exposure Chamber Acrylic Dosing Chamber

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