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Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
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JoVE Journal Medicina
Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

DOI:
10.3791/55599-v

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09:24 min

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April 17, 2017

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, , ,
1Neuroscience Graduate Program,University of Cincinnati, 2Department of Biological Sciences,Wright State University, 3Division of Neurosurgery,Cincinnati Children’s Hospital Medical Center

Capítulos

  • 00:05Título
  • 00:48Preparation for Surgery
  • 02:24Implanting the Telemetry Device to Record Scalene and Trapezius EMG Activity
  • 07:01Acquiring Simultaneous Electromyography and Plethysmography Signals
  • 08:00Results: Representative Whole-body Plethysmography (WBP) and Electromyography Traces
  • 08:56Conclusion

Summary

Tadução automática

Tadução automática

This paper introduces a method for repeated measurements of ventilation and respiratory muscle activity in a freely behaving amyotrophic lateral sclerosis (ALS) mouse model throughout disease progression with whole-body plethysmography and electromyography via an implanted telemetry device.

Tags

Keywords: Respiratory Muscle ActivityVentilationMouse ModelsNeuromuscular DiseaseTelemetry DeviceElectromyographyDiaphragm FunctionALSSpinal Cord InjuryEMG ElectrodesAnesthesiaSurgical ImplantationRespiratory MusclesAccessory Respiratory Muscles

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