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Ingeniería tisular tridimensional alineado astrositos redes para recapitular los mecanismos del desarrollo y facilitar la regeneración del sistema nervioso
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1Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine,University of Pennsylvania, 2Center for Neurotrauma, Neurodegeneration & Restoration,Michael J. Crescenz Veterans Affairs Medical Center, 3School of Biomedical Engineering,Drexel University, 4Department of Bioengineering, School of Engineering and Applied Sciences,University of Pennsylvania, 5Neuroscience Graduate Group, Perelman School of Medicine,University of Pennsylvania
Capítulos
- 00:05Título
- 01:03Agarose Hydrogel Micro-Column Fabrication
- 03:51ECM Core Fabrication
- 05:26Seeding Micro-columns with Astrocytes
- 06:32Results: Formation of Astrocyte Bundles within Hydrogel Micro-columns over Time
- 07:54Conclusion
Nos muestra el desarrollo de los paquetes uno mismo-montado, tridimensionales de somata astrocytic longitudinalmente alineado y procesos dentro de un protector nuevo biomaterial. Estos diseñados "andamios de vida", que diámetro de la escala del micrón pero extiende centímetros de longitud, puede servir como bancos de pruebas para estudiar los mecanismos del desarrollo neurológico o facilitar la Neurorregeneración por dirige la migración neuronal y axonal pathfinding.
Tags
Astrocyte NetworksAligned AstrocytesNervous System RegenerationMicrogel Micro-columnsGlial TubesRostral Migratory StreamAgarose HydrogelIn Vitro Neuro-biological ModelNeuro-regenerative TherapyCell MigrationAxon PathfindingGlial-mediated DevelopmentTraumaNeurodegenerative DiseaseCentral Nervous SystemRegenerationTreatment StrategiesNeuroanatomyGlia-mediated MechanismsAcupuncture NeedleCapillary TubeMicro-column BoatsAgarose SolutionDPBSMicro Scalpel
