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1Research Service,VA Western New York Healthcare System, 2Department of Ophthalmology, (Ross Eye Institute), Jacobs School of Medicine and Biomedical Sciences,University at Buffalo- SUNY, 3Pharmacology/Toxicology, Jacobs School of Medicine and Biomedical Sciences,University at Buffalo- SUNY, 4Physiology/Biophysics, Jacobs School of Medicine and Biomedical Sciences,University at Buffalo- SUNY, 5Neuroscience Program, Jacobs School of Medicine and Biomedical Sciences,University at Buffalo- SUNY, 6The RNA Institute,University at Buffalo- SUNY, 7The SUNY Eye Institute
Capítulos
- 00:04Título
- 00:45Subretinal Injection
- 02:37Injection Site and Subretinal Bleb Mapping
- 04:03High Resolution Spectral-Domain Optical Coherence Tomography (HR-SD-OCT) Outer Retinal Degeneration Evaluation
- 07:47Results: Representative Outer Retinal Change Quantification and Post-Subretinal Injection 3D Mapping
- 08:54Conclusion
Nous démontrons une nouvelle approche à l’utilisation de tomographie à cohérence optique domaine spectral haute résolution (HR-SD-OCT) pour aider l’administration d’agents de thérapie génique dans l’espace sous-rétinienne, évaluer sa couverture areal et caractériser la vitalité des photorécepteurs.
Tags
Ultrahigh ResolutionMouseOptical Coherence TomographyIntraocular InjectionRetinal Gene TherapySubretinal InjectionVector DeliveryTherapeutic Agent ToxicityMinimally InvasiveReproducibleReal-time ObservationRetinal ImagingProptosisScleral DepressionRetinal Pigment EpitheliumSubretinal SpaceInjection OutcomesOCT Imaging
