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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
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JoVE Journal Medicina
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

DOI:
10.3791/56095-v

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08:17 min

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August 25, 2017

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, , ,
1Cellular Biomedicine Group, Shanghai, 2Cellular Biomedicine Group, Cupertino, 3Department of Respiratory Medicine, Shanghai General Hospital,Shanghai Jiaotong University

Capítulos

  • 00:05Título
  • 00:52Ozone Air Exposure and Treadmill Test
  • 02:17Pulmonary Function Measurements
  • 03:05Broncheoalveolar Lavage Fluid (BALF) Collection
  • 04:25Cardiac Blood Sampling and Lung Morphometric Analysis
  • 06:06Results: Representative Chronic Obstructive Pulmonary Disease Mouse Model
  • 07:29Conclusion

Summary

Tadução automática

Tadução automática

This study describes the successful generation of a new chronic obstructive pulmonary disease (COPD) animal model by repeatedly exposing mice to high concentrations of ozone.

Tags

Keywords: COPD ModelOzone ExposureMiceLung FunctionMicro-CT ImagingTreadmill TestBronchoalveolar Lavage

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