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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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Medicina
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JoVE Journal Medicina
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

DOI:
10.3791/56158-v

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05:08 min

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September 20, 2017

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, ,
1Latner Thoracic Surgery Research Laboratories,University Health Network, 2Department of Pediatrics,British Columbia Children’s Hospital & University of British Columbia, 3Institute of Medical Science,University of Toronto

Capítulos

  • 00:05Título
  • 00:37Preparation of Amino Acid Solutions
  • 01:16Preparation of SAP-AA Solutions
  • 01:56Preparation of Drug-DMSO or Drug-Ethanol Stock Solutions and Drug Formulations
  • 03:11Solubility Testing
  • 03:36Results: Enhancement of Hydrophobic Compound Solubility in Aqueous Solution with Self-assembling Peptide and Amino Acid Solutions
  • 04:16Conclusion

Summary

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This protocol describes a clinically-applicable means of dissolving hydrophobic compounds in an aqueous environment using combinations of self-assembling peptide and amino acid solutions. Our method resolves a major limitation of hydrophobic therapeutics, which lack safe, efficient means of solubility and delivery methods into clinical settings.

Tags

SolubilityHydrophobic CompoundsAqueous SolutionSelf-assembling PeptideAmino AcidDrug DeliveryCo-solventsDMSOEthanolFormulationVortexSonication

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