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Construction and Evaluation of a Murine Calvarial Osteolysis Model by Exposure to CoCrMo Particles in Aseptic Loosening
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JoVE Journal Medicina
Construction and Evaluation of a Murine Calvarial Osteolysis Model by Exposure to CoCrMo Particles in Aseptic Loosening

Construction and Evaluation of a Murine Calvarial Osteolysis Model by Exposure to CoCrMo Particles in Aseptic Loosening

DOI:
10.3791/56276-v

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09:46 min

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February 17, 2018

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, , , , , , , , ,
1Department of Orthopedics, Jinling Hospital, School of Medicine,Nanjing University, 2Center for Translational Medicine,Nanjing University Medical School, 3Jiangsu Key Laboratory for Molecular Medicine,Nanjing University Medical School

Capítulos

  • 00:00Título
  • 01:48Preparation of CoCrMo particles
  • 03:12Construction of Calvarial Osteolysis Model
  • 04:46Evaluation of Calvarial Osteolysis Model (two weeks later)
  • 06:18Results of Murine Calvarial Osteolysis Model
  • 07:21Conclusion

Summary

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Tadução automática

This manuscript describes a murine calvarial osteolysis model by exposure to CoCrMo particles, which constitutes an ideal animal model for assessing the interactions between wear particles and various cells in aseptic loosening.

Tags

Keywords: Murine Calvarial Osteolysis ModelCobalt-chromium-molybdenum NanoparticlesAseptic LooseningWear Particle-induced OsteolysisArthroplasty FailureCobalt Alloy ParticlesTransmission Electron MicroscopyParticle Size DistributionEndotoxin Removal

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