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抗有丝分裂药物多西紫杉醇的前列腺癌细胞模型的建立

JoVE Journal
Pesquisa do Câncer

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JoVE Journal Pesquisa do Câncer

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

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抗有丝分裂药物多西紫杉醇的前列腺癌细胞模型的建立

DOI:

10.3791/56327-v

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06:44 min

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September 08, 2017

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Lisa Mohr, Marc Carceles-Cordon, Jungreem Woo, Carlos Cordon-Cardo, Josep Domingo-Domenech, Veronica Rodriguez-Bravo²

¹Department of Pathology, Tisch Cancer Institute,Icahn School of Medicine at Mount Sinai, ²Department of Oncological Sciences, Tisch Cancer Institute,Icahn School of Medicine at Mount Sinai

Capítulos

00:05Título
00:52Generation of Docetaxel-resistant Prostate Cancer Cells
03:33Functional Characterization of Acquired Docetaxel Resistance by Colony Formation Assay
05:10Results: Generation of Docetaxel-resistant Prostate Cancer Cell Model Systems and Functional Characterization of Docetaxel Resistance
06:14Conclusion

Summary

Tadução automática

抗肿瘤治疗有助于疾病的进展和死亡。确定阻力的机械基础对于改善治疗反应是至关重要的。这份手稿详细的协议, 以产生紫杉抗性细胞模型的前列腺癌 (pc), 以帮助解剖的路径涉及的进展, 多西紫杉醇耐药性的 pc 患者。

Tags

Docetaxel-resistant Prostate Cancer Cell Models Cancer Cell Resistance Anti-mitotic Therapy Resistance Drug Response Models Cell Line Development DU145 Cells 22Rv1 Cells Dose Escalation Cell Culture Trypsinization Cell Passaging Pooled Resistant Cells

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