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一种研究胆碱能药物早期开发中胆碱能药物中央神经系统药效学作用的计算机测试电池
JoVE Journal
Neurociência
This content is Free Access.
JoVE Journal Neurociência
A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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一种研究胆碱能药物早期开发中胆碱能药物中央神经系统药效学作用的计算机测试电池

DOI:
10.3791/56569-v

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07:02 min

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February 11, 2019

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, , , , , ,
1Centre for Human Drug Research (CHDR), Leiden

Capítulos

  • 00:04Título
  • 00:36Adaptive Tracking Test
  • 01:35Saccadic Eye Movement and Smooth Pursuit Test
  • 03:28Visual Analog Scale, Body Sway and Visual Verbal Learning Test
  • 05:32Results: Effect of Placebo, Mecamylamine, and Scopolamine on the Adaptive Tracking Test in Healthy Young Males
  • 06:08Conclusion

Summary

Tadução automática

Tadução automática

一个经过验证的计算机电池的神经心理和神经生理测试被用来研究药效学影响的中枢神经系统在早期阶段的发展。为了证明测试电池, 描述了 mecamylamine 的急性影响和两种激动剂药物逆转这些影响。

Tags

PharmacodynamicCentral Nervous SystemCholinergic DrugsEarly Phase Drug DevelopmentNeuropsychologicalNeurophysiologicalTest BatteryRepeated MeasurementsConcentration Effects RelationshipsDose EscalationComputerized TestEye ElectrodesEEGSubject Performance

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